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Results for "

BV-2 microglial cell

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) Bacterial (1) Cannabinoid Receptor (1) COX (1) ERK (2) Fungal (1) GSK-3 (1) Interleukin Related (1) Isotope-Labeled Compounds (1) Keap1-Nrf2 (2) Leukotriene Receptor (1) mGluR (2) NF-κB (2) NO Synthase (5) Parasite (1) TNF Receptor (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (12) Metabolic Disease (1) Neurological Disease (4)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Itk TOPK NAMPT ALCAM/CD166 GDNF Receptor BCL6 Tim3

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-155572

Nrf2 activator-8	Keap1-Nrf2	Inflammation/Immunology
Nrf2 activator-8 (compound 10e) is a Nrf2 activator (EC₅₀=37.9 nM). Nrf2 activator-8 exhibits remarkable antioxidant and anti-inflammatory effects in BV-2 microglial cells. Nrf2 activator-8 can significantly restore spatial memory deficits in a mouse model of lipopolysaccharide (LPS)-induced neuroinflammation .

HY-N10066

Anti-inflammatory agent 5

Others Inflammation/Immunology

Anti-inflammatory agent 5 displays potent inhibition of NO generation in lipopolysaccharide-induced BV-2 microglial cells.
HY-N3760

Dimeric coniferyl acetate

NO Synthase Inflammation/Immunology

Dimeric coniferyl acetate is a NO production inhibitor with an IC₅₀ value 7.9 μM in BV-2 microglial cells .

Anti-inflammatory agent 5	Others	Inflammation/Immunology
Anti-inflammatory agent 5 displays potent inhibition of NO generation in lipopolysaccharide-induced BV-2 microglial cells.

Dimeric coniferyl acetate	NO Synthase	Inflammation/Immunology
Dimeric coniferyl acetate is a NO production inhibitor with an IC₅₀ value 7.9 μM in BV-2 microglial cells .

HY-N10275

Herpotrichone A	Others	Inflammation/Immunology
Herpotrichone A shows potent anti-neuroinflammatory activity in lipopolysaccharide (LPS)-induced BV-2 microglial cells with the half maximal inhibitory concentration (IC₅₀) value of 0.41 μM.

HY-N10274

Herpotrichone B	Others	Neurological Disease Inflammation/Immunology
Herpotrichone B shows potent anti-neuroinflammatory activity in lipopolysaccharide (LPS)-induced BV-2 microglial cells with the half maximal inhibitory concentration (IC₅₀) value of 0.11 μM.

HY-N3473

Isomaculosidine	NO Synthase	Neurological Disease
Isomaculosidine is an alkaloid that can be isolated from D. dasycarpus. Isomaculosidine can inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV2 microglial cells .

HY-138050

Nyasol (-)-Nyasol; (Z)-Hinokiresinol; cis-Hinokiresinol	NO Synthase Bacterial Fungal Parasite Leukotriene Receptor	Infection Inflammation/Immunology
Nyasol ((-)-Nyasol) is an active compound that has antifungal, antibacterial, antileishmanial, hyaluronidase inhibition activities. Nyasol inhibits LTB4 binding to human neutrophils. Nyasol suppresses neuroinflammatory response through the inhibition of I-κB degradation in LPS (HY-D1056)-stimulated BV-2 microglial cells .

HY-146168

Nrf2 activator-5	Keap1-Nrf2	Inflammation/Immunology
Nrf2 activator-5 (compound 1) is a potent Nrf2 activator that can attenuate H₂O₂-induced oxidative stress and LPS-stimulated inflammation in BV-2 microglial cells. Nrf2 activator-5 exhibits antioxidant and anti-inflammatory activities .

HY-N2259

Curcumenol 2 Publications Verification (+)-Curcumenol
Curcumenol ((+)-Curcumenol) is a potent CYP3A4 inhibitor with an IC₅₀ of 12.6 μM, which is one of constituents in the plants of medicinally important genus of Curcuma zedoaria, with neuroprotection, anti-inflammatory, anti-tumor and hepatoprotective activities. Curcumenol ((+)-Curcumenol) suppresses Akt-mediated NF-κB activation and p38 MAPK signaling pathway in LPS-stimulated BV-2 microglial cells .

HY-N4190

Britannilactone diacetate 1,6-O,O-Diacetylbritannilactone; Di-O-acetylbritannilactone	NO Synthase	Neurological Disease Inflammation/Immunology
Britannilactone diacetate (1,6-O,O-Diacetylbritannilactone; Compound 2) exhibits potential NO inhibition effect. Britannilactone diacetate exhibits activity against NO production induced by LPS in BV-2 microglial cells with the EC₅₀ value of 6.3 μM. Britannilactone diacetate exhibits a favorable blood-brain barriers (BBB) penetration and absorption, distribution, metabolism, excretion, and toxicity (ADMET) property .

HY-101364

CHPG	mGluR NF-κB ERK Akt	Cardiovascular Disease Inflammation/Immunology
CHPG is a selective mGluR5 agonist, and attenuates SO₂-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells . CHPG protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways .

HY-101364A

CHPG sodium salt	mGluR NF-κB ERK Akt	Neurological Disease Inflammation/Immunology
CHPG sodium salt is a selective mGluR5 agonist, and attenuates SO₂-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells . CHPG sodium salt protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways. .

HY-N8371

Shizukaol B	NO Synthase COX Interleukin Related TNF Receptor	Inflammation/Immunology
Shizukaol B is a lindenane-type dimeric sesquiterpene, used to be isolated from the whole plant of Chloranthus henryi. Shizukaol B has anti-inflammatory effect against lipopolysaccharide (LPS)-induced activation of BV2 microglial cells. Shizukaol B inhibits iNOS and COX-2, and suppresses NO production, TNF-α, and IL-1β expression .

HY-10512S

AR-A014418-d3 AR 0133418-d₃; GSK 3β inhibitor VIII-d₃; AR 014418-d₃	Isotope-Labeled Compounds GSK-3	Metabolic Disease Cancer
AR-A014418-d₃ is the deuterium labeled AR-A014418. AR-A014418 is a potent, selective, and ATP-competitive GSK3β inhibitor (IC50=104 nM; Ki=38 nM)[1].

HY-147512

CB1/2 agonist 1	Cannabinoid Receptor	Inflammation/Immunology
CB1/2 agonist 1 is a potent and cross the blood-brain barrier CB1/2 agonist with EC₅₀s of 56.15, 11.63 nM for CB1R and CB2R, respectively. CB1/2 agonist 1 reduces glutamate release and LPS-induced activation of microglial cells. CB1/2 agonist 1 shows anti-inflammatory and antinociceptive effects. CB1/2 agonist 1 has the potential for the research of multiple sclerosis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N3473

Isomaculosidine	Alkaloids Dictamnus dasycarpus Turcz. Source classification Rutaceae Quinoline Alkaloids Plants	NO Synthase
Isomaculosidine is an alkaloid that can be isolated from D. dasycarpus. Isomaculosidine can inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV2 microglial cells .

HY-N10066

Anti-inflammatory agent 5	Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Disease Research Fields Inflammation/Immunology	Others
Anti-inflammatory agent 5 displays potent inhibition of NO generation in lipopolysaccharide-induced BV-2 microglial cells.

HY-N3760

Dimeric coniferyl acetate	Structural Classification Monophenols Source classification Jatropha integerrima Jacq. Phenols Euphorbiaceae Plants	NO Synthase
Dimeric coniferyl acetate is a NO production inhibitor with an IC₅₀ value 7.9 μM in BV-2 microglial cells .

HY-N10275

Herpotrichone A	Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Inflammation/Immunology	Others
Herpotrichone A shows potent anti-neuroinflammatory activity in lipopolysaccharide (LPS)-induced BV-2 microglial cells with the half maximal inhibitory concentration (IC₅₀) value of 0.41 μM.

HY-N10274

Herpotrichone B	Natural Products Microorganisms Source classification	Others
Herpotrichone B shows potent anti-neuroinflammatory activity in lipopolysaccharide (LPS)-induced BV-2 microglial cells with the half maximal inhibitory concentration (IC₅₀) value of 0.11 μM.

HY-138050

Nyasol (-)-Nyasol; (Z)-Hinokiresinol; cis-Hinokiresinol	Structural Classification Source classification Phenols Polyphenols Hypoxis angustifolia Lam. Plants Asparagaceae Juss.	NO Synthase Bacterial Fungal Parasite Leukotriene Receptor
Nyasol ((-)-Nyasol) is an active compound that has antifungal, antibacterial, antileishmanial, hyaluronidase inhibition activities. Nyasol inhibits LTB4 binding to human neutrophils. Nyasol suppresses neuroinflammatory response through the inhibition of I-κB degradation in LPS (HY-D1056)-stimulated BV-2 microglial cells .

HY-N8371

Shizukaol B	Structural Classification Terpenoids Sesquiterpenes Source classification Chloranthaceae Plants Chloranthus henryi Hemsl.	NO Synthase COX Interleukin Related TNF Receptor
Shizukaol B is a lindenane-type dimeric sesquiterpene, used to be isolated from the whole plant of Chloranthus henryi. Shizukaol B has anti-inflammatory effect against lipopolysaccharide (LPS)-induced activation of BV2 microglial cells. Shizukaol B inhibits iNOS and COX-2, and suppresses NO production, TNF-α, and IL-1β expression .

Cat. No.	Product Name	Chemical Structure

HY-10512S

AR-A014418-d3

AR-A014418-d₃ is the deuterium labeled AR-A014418. AR-A014418 is a potent, selective, and ATP-competitive GSK3β inhibitor (IC50=104 nM; Ki=38 nM)[1].

AR-A014418-d3
AR-A014418-d₃ is the deuterium labeled AR-A014418. AR-A014418 is a potent, selective, and ATP-competitive GSK3β inhibitor (IC50=104 nM; Ki=38 nM)[1].

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BV-2 microglial cell

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Natural
Products